Hexamethylene bisacetamide as a chemopreventive agent in hamster cheek pouch tumorigenesis

Y. Yura, H. Tsujimoto, J. Kusaka, H. Yoshida, M. Sato
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引用次数: 3

Abstract

The chemopreventive effect of oral and intraperitoneal (i.p.) administration of hexamethylene bisacetamide (HMBA) on 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced tumour formation in hamster cheek pouches was investigated. Male Syrian hamsters were treated by painting both cheek pouches with a 0.5% solution of DMBA twice weekly for 11 weeks. In addition to DMBA application, Group 1 hamsters were given 1% HMBA continuously in the drinking water and Group 2 hamsters received i.p. injection of HMBA at a dose of 500 mg/kg three times per week during the experiment. Group 3 animals received DMBA application alone. Thirteen weeks after the start of the experiment, the numbers of cheek pouch tumours and tumour volume were significantly decreased by oral but not i.p. administration of HMBA. Low levels of HMBA were detected in the plasma of the hamsters which were given 1% HMBA in drinking water. These results indicate that oral administration of HMBA can act as a chemopreventive agent against hamster cheek pouch tumorigenesis.

六亚甲基双乙酰胺在仓鼠颊袋肿瘤发生中的化学预防作用
研究了口服和腹腔注射六亚甲基双乙酰胺(HMBA)对9,10-二甲基-1,2-苯并蒽(DMBA)诱导的仓鼠颊袋肿瘤形成的化学预防作用。用0.5% DMBA溶液涂抹雄性叙利亚仓鼠双颊袋,每周2次,持续11周。除DMBA外,1组仓鼠在饮水中连续给予1%的HMBA, 2组仓鼠在实验期间每周3次ig注射剂量为500 mg/kg的HMBA。第三组动物单独应用DMBA。实验开始13周后,口服HMBA可显著减少大鼠颊袋肿瘤的数量和肿瘤体积,而非口服HMBA。在饮水中给予1% HMBA的仓鼠血浆中检测到低水平的HMBA。这些结果表明,口服HMBA可作为一种化学预防剂,预防仓鼠颊袋肿瘤的发生。
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