[Immunotoxicity of chemicals].

Abstract

Immunotoxicity is the detrimental effects of xenobiotics on immune functions of hosts, which result in enhanced susceptibility to infectious agents and tumours. A variety of environmental chemicals, such as pharmaceuticals, food additives, contaminating chemicals in food and drinking water, pesticides, and airborne chemicals, have been reported to exert immunotoxic effects on experimental animals and humans. In this paper, the mechanisms of immune responses, the effects of typical immunotoxic chemicals on the immune systems, and the methods for detecting immunotoxicity were described. In addition, the strategies and guidelines for immunotoxicity assessment were briefly outlined and discussed.