[Glycyrrhitinic acid reference standard (Control 941) of the National Institute of Health Sciences].

S Okada, A Kitajima, T Tanimoto, H Suzuki, M Satake
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Abstract

The raw material of glycyrrhitinic acid was examined for preparation of the "Glycyrrhitinic Acid Reference Standard". The candidate material was evaluated physico-chemically by a collaborative study in which five laboratories participated. Analytical data obtained were as follows: UV spectrum, lambda max = 251 nm and specific absorbance E1%1cm (EtOH) at the lambda max = 145; IR spectrum, specific absorption numbers were at 1719, 1654, 1216, and 1170 cm-1; thin-layer chromatography, some laboratories detected a trace amount of one spot and others not detected; high-performance liquid chromatography, 2-6 impurities were detected and the amount of any impurities were estimated to be less than 0.2% and the total amount less than 0.5%. Based on the above results, the candidate material was authorized as the Glycyrrhitinic Acid Reference Standard of National Institute of Health Sciences.

【国家卫生科学研究所甘草酸参比标准(Control 941)】。
为编制《甘草酸标准品》,对甘草酸的原料进行了考察。候选材料通过五个实验室参与的合作研究进行物理化学评估。得到的分析数据如下:紫外光谱,λ max = 251 nm,比吸光度E1%1cm (EtOH), λ max = 145;红外光谱,比吸收数分别为1719、1654、1216和1170 cm-1;薄层色谱法,有的实验室检测到痕量的一个点,有的没有检测到;高效液相色谱法检出2 ~ 6种杂质,其中任何一种杂质的含量均小于0.2%,杂质总量均小于0.5%。根据上述结果,该候选物质被批准为国家卫生科学研究院甘草酸参考标准品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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