Battling against host phagocytes: the wherefore of the RTX family of toxins?

Infectious agents and disease Pub Date : 1995-12-01
R A Welch, M E Bauer, A D Kent, J A Leeds, M Moayeri, L B Regassa, D L Swenson
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Abstract

The RTX family of bacterial exotoxins is a group of related cytolytic proteins produced by a wide variety of gram-negative human and animal pathogens. While diverse in their associated diseases and in their target cell specificities, there remain several themes common to RTX toxins, including genetic organization, structural and functional features, and effects on target cells. In this review, we summarize and discuss the genetics, regulation, epidemiology, structure/function relationships, and in vivo and in vitro activities of the best characterized RTX toxins, and speculate on their roles in pathogenesis and their use in immunotherapy.

对抗宿主吞噬细胞:RTX毒素家族的原因?
细菌外毒素RTX家族是由多种革兰氏阴性人类和动物病原体产生的一组相关的细胞溶解蛋白。尽管RTX毒素的相关疾病和靶细胞特异性各不相同,但它们仍有几个共同的主题,包括遗传组织、结构和功能特征以及对靶细胞的影响。在本文中,我们总结和讨论了最具特征的RTX毒素的遗传、调控、流行病学、结构/功能关系、体内和体外活性,并推测其在发病机制中的作用及其在免疫治疗中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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