[Effect of administration of blood products on the course of tetanus antibody concentration in immuno-incompetent patients].

Infusionstherapie und Transfusionsmedizin Pub Date : 1996-02-01

M Pietsch, S Töre, K H Schütt

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Abstract

Objective: Collecting of data for immunoprophylaxis of tetanus in immunodeficient patients via administration of blood products.

Design: Prospective single case studies.

Setting: Clinical therapy in a department of hematology with continuous determination of tetanus antibody concentrations in patients' sera and administered blood products with an enzyme immunoassay.

Patients: 3 patients with acute myeloid leukemia (FAB classifications M1, M3, M4).

Interventions: Regular administration of blood products due to clinical therapy.

Results: After administration of about 4,000 IU tetanus antitoxin i.v., serum concentration is increasing by 1 IU/ml. Half life in serum amounts to 7 days. Protection lasts therefore up to 6 weeks.

Conclusions: Immunodeficient patients may receive a medium-term effective protection against tetanus after selection of suitable blood products. This method is interesting also for prophylaxis of postoperative tetanus in immunocompetent patients.

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血液制品对免疫功能不全患者破伤风抗体浓度变化的影响。

目的:收集免疫缺陷患者血液制品免疫预防破伤风的资料。设计:前瞻性单一案例研究。环境:血液科的临床治疗，连续测定患者血清中的破伤风抗体浓度，并用酶免疫测定法给予血液制品。患者:急性髓系白血病3例(FAB分型M1、M3、M4)。干预措施:因临床治疗需定期给予血液制品。结果:注射破伤风抗毒素约4000 IU后，血清浓度升高1 IU/ml。血清中的半衰期为7天。因此，保护期长达6周。结论:免疫缺陷患者在选择合适的血液制品后，可获得中期有效的破伤风保护。该方法对免疫功能正常患者术后破伤风的预防也很有意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infusionstherapie und Transfusionsmedizin

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