kappa-1 Opioid receptors of the temporal cortex are preserved in Alzheimer's disease.

K B Mackay, D Dewar, J McCulloch
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引用次数: 9

Abstract

The binding of [3H]-U-69593 and [3H]-CI-977 to kappa-1 opioid receptors has been examined in the temporal cortex of postmortem brains from patients with Alzheimer's disease and age-matched controls using quantitative autoradiography. There was no significant difference between Alzheimer and control subjects in the level of [3H]-U-69593 and [3H]-CI-977 binding, but ChAT activity was markedly reduced (by 73% compared to controls). These results are not consistent with a presynaptic localisation of kappa-1 receptors on cholinergic terminals in human temporal cortex.

颞叶皮层kappa-1阿片受体在阿尔茨海默病中被保留。
[3H]-U-69593和[3H]-CI-977与kappa-1阿片受体的结合已在阿尔茨海默病患者和年龄匹配对照的死后大脑颞叶皮层中进行了定量放射自显影检查。阿尔茨海默病患者与对照组在[3H]-U-69593和[3H]-CI-977结合水平上无显著差异,但ChAT活性明显降低(与对照组相比降低73%)。这些结果与kappa-1受体在人类颞叶皮层胆碱能末端的突触前定位不一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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