A comparison of multiplex and simplex families with Alzheimer's disease/senile dementia of Alzheimer type within a well defined population.

I Alafuzoff, E Almqvist, R Adolfsson, S Lake, W Wallace, D A Greenberg, B Winblad
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引用次数: 4

Abstract

A study was made on 150 clinically demented patients presenting at autopsy at Umeå University Hospital in Sweden. In 90 of the cases dementia was considered to be primary in nature and of these forty six per cent (41 cases), fulfilled both the clinical and histopathological criteria for the diagnosis of Alzheimer's disease/Senile dementia of Alzheimer type (AD/SDAT). The families of these 41 AD/SDAT cases were then studied, and a family history obtained through interviews with multiple family informants and from civil and medical records. Additional diseased family members suffering from progressive dementia (multiplex families) were observed in 12 probands out of 41 (29%). Multiplex families exhibited similar clinical and histopathological characteristics as simplex families containing a single affected individual. The secondary cases in the multiplex families exhibited similar demographic and clinical characteristics as the probands. 39% of the multiplex and 14% of the simplex cases had an early age of onset of the disease, that was under 65 years. The overall prevalence of progressive dementia disorders in the 41 families was 5.9%. The prevalence of a progressive dementia disorder was 11% in the multiplex families (14% for the early onset cases) and 3.5% in the simplex families (2% for the early onset cases). The prevalence of progressive dementia disorder for family members who had passed the mean age of the onset of the disease for their family, was 45% for multiplex and 18% for simplex families. Furthermore the incidence rate for dementia was significantly higher (p < 0.005) in multiplex families (5.5 per 1,000 person years) when compared to simplex families (2.5 per 1,000 person years). No differences could be seen in parental age at birth of the diseased when comparing the two sets of families. However in multiplex families the duration of the disease was significantly (p < 0.025) shorter, in subjects with parental age at birth over 35 years compared to those with a parental age under 35 years. The multiplex families contained significantly (p < 0.025) larger sibships; and showed a significantly lower age of onset for the disease (p < 0.001), and a significantly longer duration of disease (p < 0.05) compared to the simplex families. A significant intra familial correlation of age at disease onset was observed in both sets of the families.

在一个明确界定的人群中患有阿尔茨海默病/阿尔茨海默型老年痴呆的多重和单一家族的比较
对150名在瑞典尤梅夫大学医院进行尸检的临床痴呆患者进行了研究。在90例病例中,痴呆症被认为是原发性的,其中46%(41例)符合阿尔茨海默病/阿尔茨海默型老年痴呆症(AD/SDAT)的临床和组织病理学诊断标准。然后对这41例AD/SDAT病例的家庭进行研究,并通过与多名家庭举报人的访谈以及从民事和医疗记录中获得家族史。41个先证者中有12个(29%)观察到患有进行性痴呆的患病家庭成员(多重家族)。多重家族表现出与单纯性家族相似的临床和组织病理学特征。多重家族继发病例表现出与先证者相似的人口学和临床特征。39%的多发性病例和14%的单纯性病例发病年龄较早,即65岁以下。41个家庭中进行性痴呆的总体患病率为5.9%。进行性痴呆的患病率在多重家族中为11%(早发病例为14%),在单纯性家族中为3.5%(早发病例为2%)。在超过发病平均年龄的家庭成员中,进行性痴呆的患病率在多重家庭中为45%,在单纯性家庭中为18%。此外,与单一家庭(每1000人年2.5人)相比,多重家庭(每1000人年5.5人)的痴呆发病率显著更高(p < 0.005)。当比较两组家庭时,在患病患者出生时的父母年龄没有差异。然而,在多重家庭中,父母出生时年龄大于35岁的受试者的疾病持续时间明显短于父母出生时年龄小于35岁的受试者(p < 0.025)。多元家庭的兄弟姐妹数显著大于(p < 0.025);与单纯性家庭相比,单纯性家庭的发病年龄明显降低(p < 0.001),病程明显延长(p < 0.05)。在两组家庭中均观察到发病年龄的显著家族内相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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