D2-receptor imaging with [123I]IBZM and single photon emission tomography in psychiatry: a survey of current status.

R Schlösser, S Schlegel
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引用次数: 5

Abstract

D2-dopamine receptors can be visualized in the human brain in vivo by Single Photon Emission Tomography (SPECT) and the radiolabeled benzamide [123I]IBZM. The present paper reviews the current status of this type of functional brain imaging with respect to basic methodological aspects, data analysis and quantification. The results from published clinical studies in different psychiatric patient populations and normal controls with [123I]IBZM are reviewed. [123I]IBZM-SPECT is a powerful tool for the investigation of D2-dopamine receptor status in psychiatric disorders, different types of drug treatment as well as therapeutic and side effects of pharmacologic agents. However, there still is a need for standardized imaging times and image-processing procedures. Advantages and disadvantages of SPECT with special regard to Positron Emission Tomography (PET) are also discussed.

[123I]IBZM与单光子发射断层成像在精神病学中的研究现状
d2 -多巴胺受体可以通过单光子发射断层扫描(SPECT)和放射性标记苯甲酰胺[123I]IBZM在体内观察到。本文从基本方法学、数据分析和量化等方面综述了这类脑功能成像的现状。本文回顾了已发表的不同精神病学人群和正常对照[123I]IBZM的临床研究结果。[123I]IBZM-SPECT是研究精神疾病中d2 -多巴胺受体状态、不同类型药物治疗以及药物治疗和副作用的有力工具。然而,仍然需要标准化的成像时间和图像处理程序。讨论了SPECT的优缺点,特别是正电子发射断层扫描(PET)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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