Some methodological issues in neuroradiological research in psychiatry.

T Becker, W Retz, E Hofmann, G Becker, E Teichmann, W Gsell
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引用次数: 1

Abstract

An outline is given of some of the methodological issues discussed in neuroradiological research on psychiatric illness. Strengths and shortcomings of magnetic resonance imaging (MRI) in depicting and quantifying brain structures are described. Temporal lobe anatomy and pathology are easily accessible to MRI, whereas limits on anatomical delineation hamper approaches to frontal lobe study. White matter hyperintense lesions are sensitively depicted by MRI, but specificity is limited. Distinction of vascular and primary degenerative dementia is considerably improved by CT and MRI analysis. Computed tomography (CT) and MRI have enhanced the understanding of treatable organic psychiatric disorders, e.g., normal pressure hydrocephalus. Subcortical and white matter pathology has been replicated in CT and MRI studies of late-onset psychiatric disorders, clinical overlap with cerebrovascular disease or neurodegeneration may be of import. Transcranial sonography findings of brainstem structural change specific to unipolar depression may contribute to the understanding of affective psychoses. Magnetic resonance spectroscopy and functional MRI are likely to stimulate psychiatric research in the future.

精神病学神经放射学研究中的若干方法学问题。
概述了在精神疾病的神经放射学研究中讨论的一些方法学问题。描述了磁共振成像(MRI)在描绘和量化脑结构方面的优点和缺点。颞叶解剖和病理很容易获得MRI,而解剖学描绘的限制阻碍了额叶研究的方法。MRI可灵敏地描绘白质高信号病变,但特异性有限。通过CT和MRI分析,血管性痴呆和原发性退行性痴呆的区别有了很大的提高。计算机断层扫描(CT)和MRI增强了对可治疗的器质性精神疾病的认识,例如,常压性脑积水。皮层下和白质病理已在迟发性精神疾病的CT和MRI研究中得到重复,与脑血管疾病或神经退行性疾病的临床重叠可能是重要的。单极抑郁症脑干结构改变的经颅超声检查结果可能有助于理解情感性精神病。磁共振波谱和功能性核磁共振可能会刺激未来的精神病学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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