Feedforward control of agonist-induced Ca2+ signalling by protein kinase C in airway smooth muscle cells

Abstract

In isolated bovine tracheal smooth muscle cells, the potent and specific protein kinase C inhibitor GF 109203X caused an inhibition of methacholine-and histamine-induced Ca²⁺ mobilization and influx, indicating for the first time that protein kinase C activation induced by contractile agonists exerts a positive feedforward control of Ca²⁺ signalling by these agonists.