Expression of the CD15 antigen (Lewis x) in breast cancer.

The Histochemical Journal Pub Date : 1995-09-01
S A Brooks, A J Leathem
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引用次数: 0

Abstract

The expression of the cell adhesion molecule CD15 (also known as Lewis x) by breast cancers and by adjacent normal and benign breast epithelium was investigated in a series of 98 tumours. Immunohistochemistry was performed on paraffin sections using the anti-CD15 monoclonal mouse IgM antibody Dako-M1. Some 35% of cancers expressed CD15, as did 45% of normal and 60% of hyperplasia. No association was observed between cancer cell staining, or any epithelial staining (cancer, benign and normal), and tumour size, histological grade, nodal status, age at diagnosis or the frequency of 'events' (recurrence or death). Chi-squared tests in each case were non-significant. The pattern of CD15 expression by breast cancer was frequently associated with the leading edge of invading tumour or with the outer edge of boli of carcinoma in situ, possibly suggesting a potential role in invasiveness, and with cancer cells trapped intravascularly, possibly suggesting a role in metastasis.

CD15抗原(Lewis x)在乳腺癌中的表达。
在一系列98例肿瘤中,研究了细胞粘附分子CD15(也称为Lewis x)在乳腺癌和邻近正常和良性乳腺上皮中的表达。使用抗cd15单克隆小鼠IgM抗体Dako-M1对石蜡切片进行免疫组化。大约35%的癌症表达CD15, 45%的正常肿瘤和60%的增生肿瘤表达CD15。没有观察到癌细胞染色或任何上皮染色(癌症、良性和正常)与肿瘤大小、组织学分级、淋巴结状态、诊断年龄或“事件”(复发或死亡)频率之间的关联。卡方检验在每种情况下均无显著性。CD15在乳腺癌中的表达模式经常与侵袭性肿瘤的前缘或原位癌的外缘相关,可能提示其在侵袭性中起潜在作用,而与癌细胞困在血管内有关,可能提示其在转移中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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