[Appearance of anti-DNA antibodies after treatment with interferon in a patient with chronic type C viral hepatitis].

Abstract

The development of autoantibodies and autoimmune reactions has been reported during and after interferon (IFN) therapy. We report the case of a 55-years-old woman who developed anti-DNA and anti-nuclear antibodies after a 9 months treatment with alpha-IFN for chronic hepatitis C. Autoantibodies appearance has not modified the response to therapy; no clinical sign of autoimmune disease is appeared in a 5 months follow-up. HLA typing didn't show a genetic predisposition for the development of autoimmune reactions.