Human transplacental transfer of carbidopa/levodopa.

C A Merchant, G Cohen, C Mytilineou, A DiRocco, D Moros, S Molinari, M D Yahr
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引用次数: 18

Abstract

A paucity of information is available concerning the use of levodopa and carbidopa during pregnancy. Particularly lacking is whether these agents cross the placenta and whether levodopa undergoes metabolism in the fetus. The present study carried out in aborted fetal tissues demonstrates that levodopa crosses the placental barrier and suggests that it may be metabolized in fetal tissues, including the brain and spinal cord. The possibility exists that early exposure to levodopa or dopamine may alter the normal neuronal development in the fetus, and caution in the use of levodopa during pregnancy should be observed.

卡比多巴/左旋多巴的人胎盘移植。
关于怀孕期间使用左旋多巴和卡比多巴的信息缺乏。尤其缺乏的是这些药物是否穿过胎盘以及左旋多巴是否在胎儿体内进行代谢。目前在流产胎儿组织中进行的研究表明,左旋多巴穿过胎盘屏障,并表明它可能在胎儿组织中代谢,包括脑和脊髓。早期接触左旋多巴或多巴胺可能会改变胎儿正常的神经元发育,妊娠期使用左旋多巴应谨慎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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