Effect of age and disease duration on parkinsonian motor scores under levodopa therapy.

G Ransmayr, G Künig, M Neubauer, M Wagner, M Falk
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引用次数: 14

Abstract

One hundred and fifty patients suffering from Parkinson's disease were analysed for the expression of the motor symptoms during optimum response to levodopa therapy (subscale III of the Unified-Parkinson's Disease Rating Scale). Patients were grouped according to age (< or = 64, 65-74, > or = 75 years). Disease duration and daily levodopa dosage were similar in the three groups. Pooled residual scores for posture and gait impairment (PGI), tremor (T), rigidity (R) and distal motor impairment (DMI; hand and foot movements) increased with age (Kruskal-Wallis ANOVA). The parkinsonian scores were significantly higher than the scores of 150 age-matched normal controls (Mann-Whitney U test). The differences between the patients' scores and the scores of the age-matched controls increased with age. In spite of a significant increase in the daily levodopa dosage with disease duration (linear regression), PGI aggravated age-dependently, and DMI age-independently with symptom duration (Spearman rank correlation). In contrast, T and R did not increase with disease duration.

年龄和病程对左旋多巴治疗帕金森运动评分的影响。
我们分析了150名帕金森病患者在左旋多巴治疗最佳反应期间的运动症状表达(统一帕金森病评定量表的亚量表III)。患者按年龄分组(<或= 64岁,65-74岁,>或= 75岁)。三组患者病程及日左旋多巴用量相似。姿势和步态障碍(PGI)、震颤(T)、僵硬(R)和远端运动障碍(DMI)的汇总残差评分;手和脚的运动)随年龄增加而增加(Kruskal-Wallis方差分析)。帕金森得分明显高于150名年龄匹配的正常对照(Mann-Whitney U检验)。随着年龄的增长,患者的得分与年龄匹配的对照组的得分之间的差异越来越大。尽管每日左旋多巴剂量随疾病持续时间显著增加(线性回归),PGI加重与年龄相关,DMI加重与症状持续时间无关(Spearman秩相关)。相比之下,T和R不随病程的延长而增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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