[The radioprotective effect of GABA-tropic substances, gamma-hydroxybutyrate and piracetam].

Radiobiologiia Pub Date : 1993-01-01
V I Kulinskiĭ, A D Klimova
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Abstract

From experiments in mice, it is shown that with a radiation dose of 8 Gy (LD96) the radioprotective effect was exerted by gamma-aminobutyric acid (GABA), substances that increase its concentration in tissues (progabide and valproate), and synthetic agonists of both receptor types, particularly baclofen, a GABA-receptor agonist. The radioprotective effect is also exerted by gamma-hydroxybutyrate, not piracetam.

[γ -羟丁酸和吡拉西坦对γ -羟丁酸和γ -羟丁酸的辐射防护作用]。
小鼠实验表明,在8 Gy (LD96)的辐射剂量下,γ -氨基丁酸(GABA)、增加其在组织中的浓度的物质(丙戊酸和丙戊酸)以及两种受体类型的合成激动剂,特别是巴氯芬(一种GABA受体激动剂)发挥了辐射防护作用。γ -羟基丁酸盐也有辐射防护作用,而吡拉西坦不起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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