[Prostaglandins content in the blood of newborns with various types of hypoxia].

Abstract

The content of prostaglandins (Pg) E, F2, 6-keto-F1 alpha, thromboxane B2 has been examined in funic blood serum and peripheral blood of 172 newborns. 38 neonates endured chronic hypoxia in the antenatal period, 42 had acute hypoxia during labour and in 39 acute hypoxia during labour developed against a background of chronic intrauterine hypoxia. The control group consisted of 53 infants that were not subjected to hypoxia during antenatal and intranatal periods. In control group in the dynamics of early neonatal period a decrease of PgE, PgE2 alpha concentration and an increase of 6-keto PgF1 alpha, TxB2 were observed. The PgE level was determined to be higher in infants with chronic hypoxia and acute hypoxia than that in the control group. In acute hypoxia the PgE concentration did not differ from that in the control group. PgF2 content was decreased in infants with chronic hypoxia and increased with acute one. The PgF alpha 1 level was noticed to decrease in chronic hypoxia and acute hypoxia against the chronic background. Thromboxane B2 concentration was increased in all the types of hypoxia. The 6 keto PgF1 alpha/TxB2 ratio decreasing in infants with all the types of hypoxia underwent the most pronounced changes. The largest deviations were marked in infants with associative hypoxia. The revealed dynamics of prostaglandin changes in the postnatal period in the control group is similar to the dynamics that reflects the course of stress-reaction under the influence of other stimuli. It permits affirming that there are common mechanisms of the prostaglandin system response to stress.(ABSTRACT TRUNCATED AT 250 WORDS)