[Anti-inflammatory activity of aqua-(aryloxyacetate) copper complexes].

Ceskoslovenska farmacie Pub Date : 1993-06-01
J Sokolík, S Sedlácková, E Racanská, M Blahová, P Svec
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引用次数: 0

Abstract

The anti-inflammatory activity of selected mononuclear Aqua(aryloxyacetato)copper(II) complexes with the composition [Cu(R-O-CH2COO)2(H2O)n].mH2O (R = phenyl, n = 3; m = 0), 4-chlorophenyl (2; 0), 4-chloro-2-methylphenyl (2; 0) and naphthyl (2; 2) was examined using rat paw dextrano edema. The antiphlogistic effects of the tested complexes were compared to those for corresponding aryloxyacetic acids and salicylic acid and its Cu(II) salt. The compounds were administered i.p. in a single effective dose of 10 mg/kg. The complexes with R = phenyl, 4-chlorophenyl and 4-chloro-2-methylphenyl exhibited a biological activity comparable to that of copper(II) salicylate tetrahydrate.

[水-(芳氧乙酸)铜配合物的抗炎活性]。
[Cu(R-O-CH2COO)2(H2O)n]单核水(芳基乙酸)铜(II)配合物的抗炎活性。mH2O (R =苯基,n = 3;M = 0), 4-氯苯基(2;0), 4-氯-2-甲基苯基(2;0)和萘基(2;2)采用大鼠足跖右旋糖酐水肿法检测。并与相应的芳氧乙酸、水杨酸及其Cu(II)盐的抗炎作用进行了比较。这些化合物以10mg /kg的单有效剂量单次给药。与R =苯基、4-氯苯基和4-氯-2-甲基苯基配合物的生物活性与四水水杨酸铜相当。
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