Effect of insulin on the decreased beta-adrenergic responses of duodenum and atrium isolated from streptozotocin diabetic rats.

General pharmacology Pub Date : 1993-01-01 DOI:10.1016/0306-3623(93)90038-y

Y Oztürk, N Yildizoğlu-Ari, V M Altan, A T Ozçelikay

{"title":"Effect of insulin on the decreased beta-adrenergic responses of duodenum and atrium isolated from streptozotocin diabetic rats.","authors":"Y Oztürk, N Yildizoğlu-Ari, V M Altan, A T Ozçelikay","doi":"10.1016/0306-3623(93)90038-y","DOIUrl":null,"url":null,"abstract":"<p><p>1. Decreased beta-adrenergic responses have been reported in both gastro-intestinal tract and atrium of experimentally-induced diabetic rats. The present study was undertaken to investigate in vitro effects of insulin on decreased beta-adrenergic responses of the duodenum and atrium from streptozotocin-diabetic rats. 2. Insulin incubation (16.67 micrograms/ml) in bathing medium for 5 hr enhanced the decreased beta-adrenergic responses in the diabetic rat duodenum, but not those in the diabetic atrium. Incubation of bovine insulin with anti-bovine insulin antibody in the test-tube inhibited the improving effect of insulin on the decreased beta-adrenergic responses of diabetic rat duodenum. 3. In vitro treatment with the same dose of bovine insulin in bathing medium caused a decrease in the beta-adrenergic responses of the atria from both non-diabetic and diabetic rats. Anti-bovine insulin antibody also abolished the inhibitory effect of insulin on the rat atria. 4. These results strongly suggest that the experimental diabetes affects beta-adrenergic responsiveness of the rat gastro-intestinal tract through a different mechanism from that of the rat myocardium.</p>","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"24 1","pages":"217-23"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(93)90038-y","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0306-3623(93)90038-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 12

Abstract

1. Decreased beta-adrenergic responses have been reported in both gastro-intestinal tract and atrium of experimentally-induced diabetic rats. The present study was undertaken to investigate in vitro effects of insulin on decreased beta-adrenergic responses of the duodenum and atrium from streptozotocin-diabetic rats. 2. Insulin incubation (16.67 micrograms/ml) in bathing medium for 5 hr enhanced the decreased beta-adrenergic responses in the diabetic rat duodenum, but not those in the diabetic atrium. Incubation of bovine insulin with anti-bovine insulin antibody in the test-tube inhibited the improving effect of insulin on the decreased beta-adrenergic responses of diabetic rat duodenum. 3. In vitro treatment with the same dose of bovine insulin in bathing medium caused a decrease in the beta-adrenergic responses of the atria from both non-diabetic and diabetic rats. Anti-bovine insulin antibody also abolished the inhibitory effect of insulin on the rat atria. 4. These results strongly suggest that the experimental diabetes affects beta-adrenergic responsiveness of the rat gastro-intestinal tract through a different mechanism from that of the rat myocardium.

查看原文本刊更多论文

胰岛素对链脲佐菌素糖尿病大鼠十二指肠和心房肾上腺素能反应下降的影响。

1. 实验诱导的糖尿病大鼠的胃肠道和心房均有β -肾上腺素能反应下降的报道。本研究旨在探讨胰岛素对链脲佐菌素糖尿病大鼠十二指肠和心房β -肾上腺素能反应降低的体外影响。2. 胰岛素(16.67微克/毫升)浸泡5小时可增强糖尿病大鼠十二指肠的β -肾上腺素能反应，但对糖尿病大鼠心房没有作用。牛胰岛素与抗牛胰岛素抗体在试管内孵育抑制了胰岛素对糖尿病大鼠十二指肠β -肾上腺素能反应下降的改善作用。3.在体外用相同剂量的牛胰岛素浸泡可使非糖尿病大鼠和糖尿病大鼠心房β -肾上腺素能反应降低。抗牛胰岛素抗体也能消除胰岛素对大鼠心房的抑制作用。4. 这些结果强烈提示，实验性糖尿病影响大鼠胃肠道β -肾上腺素能反应的机制与影响心肌的机制不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

General pharmacology

自引率

0.00%

发文量