[Effects of propafenone on the parameters of body surface electrocardiogram in comparison with those of disopyramide].

I Omori, M Ochiai, D Inoue, J Asayama, M Nakagawa
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Abstract

The purpose of this study is to investigate the clinical effects of propafenone on the QT(QTc), QRS, PQ and RR interval of body surface electrocardiogram (ECG) in comparison with the effects of disopyramide. In 10 patients (5 with paroxysmal atrial fibrillation and 5 with ventricular premature complex: ages 48-77), after 4 days' observation without any cardioactive drugs, disopyramide (300mg/day) was administered orally for 7 days. After discontinuing the administration of disopyramide, 4 more days were allowed to wash out the drug, and propafenone (450mg/day) was administered orally for 7 days. 12-lead ECG was taken twice before the administration of disopyramide (Pre-1 and -2), on the 1st, 3rd, 5th and 7th days after the administration of disopyramide. Then it was also taken on the day before the beginning of propafenone administration and on the 1st, 3rd, 5th and 7th days after the administration of propafenone. The corrected QT (QTc = QT/square root of RR), QRS, PQ and RR intervals in lead II or V2 of each ECG were measured as the mean value of 5 consecutive sinus beats. The control values of QTc, QRS, PQ and RR intervals were calculated as the mean values of Pre-1 and -2, and the other values were expressed as the % ratio to the control values. Propafenone hardly altered the QTc interval but prolonged QRS interval after the 5th day of administration (110 +/- 12%, p < 0.05), while disopyramide significantly prolonged the QTc interval after the 3rd day of administration (109 +/- 5%, p < 0.001) without affecting the QRS interval.(ABSTRACT TRUNCATED AT 250 WORDS)

[普罗帕酮对体表心电图参数的影响,与二丙酰胺的比较]。
本研究旨在探讨普罗帕酮对体表心电图(ECG) QT(QTc)、QRS、PQ及RR间期的临床影响,并与二丙酰胺的影响进行比较。10例患者(阵发性心房颤动5例,室性早发综合征5例,年龄48 ~ 77岁),观察4 d后,不使用任何心脏活性药物,口服双哌嗪(300mg/d) 7 d。停药后再给药4天,再给药450mg/天,口服普罗帕酮7天。给药前分别于给药后第1天、第3天、第5天、第7天分别取2次12导联心电图(Pre-1和-2)。然后在普罗帕酮开始给药的前一天以及普罗帕酮给药后的第1、3、5、7天服用。测量校正QT (QTc = QT/ RR的平方根)、QRS、PQ和各心电图II导联或V2导联RR间期作为连续5次窦性搏动的平均值。QTc、QRS、PQ和RR区间的控制值以Pre-1和-2的平均值计算,其他值以与控制值的%比值表示。propacenone对QTc间期影响不大,但使给药第5天QRS间期延长(110 +/- 12%,p < 0.05),而disopyamide显著延长给药第3天QTc间期(109 +/- 5%,p < 0.001),但不影响QRS间期。(摘要删节250字)
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