S Kakinoki, S Takechi, M Hashimoto, I Sakuma, A Nomura, A Kitabatake, H Yasuda
{"title":"[Effect of enalapril on left ventricular hypertrophy and left ventricular function in patients with hypertension].","authors":"S Kakinoki, S Takechi, M Hashimoto, I Sakuma, A Nomura, A Kitabatake, H Yasuda","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of this study was to study the effect of enalapril (E) on left ventricular (LV) mass, LV function and blood renin-angiotensin (RA) in patients with hypertension. Sixteen hypertensives were included in this study (WHO I 8, WHO II 8, 49.5 +/- 10.5 yrs). They were examined for blood pressure and heart rate. Chest X-ray film, echocardiography (echo), X-ray computed tomography (CT) and RA before and after about 6 months of E administration were studied. The LV mass was calculated by CT. The LV function was measured by echo. RAS was unchanged during this study. LV mass was significantly reduced after E (121.4 +/- 25.6 vs 104.6 +/- 13.7 g/cm2). The LV systolic function was unchanged after E, but LV diastolic function improved. It was shown that the long-term administration of E improves LV hypertrophy and LV diastolic function without any change of RAS.</p>","PeriodicalId":76077,"journal":{"name":"Kokyu to junkan. Respiration & circulation","volume":"41 12","pages":"1185-9"},"PeriodicalIF":0.0000,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kokyu to junkan. Respiration & circulation","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of this study was to study the effect of enalapril (E) on left ventricular (LV) mass, LV function and blood renin-angiotensin (RA) in patients with hypertension. Sixteen hypertensives were included in this study (WHO I 8, WHO II 8, 49.5 +/- 10.5 yrs). They were examined for blood pressure and heart rate. Chest X-ray film, echocardiography (echo), X-ray computed tomography (CT) and RA before and after about 6 months of E administration were studied. The LV mass was calculated by CT. The LV function was measured by echo. RAS was unchanged during this study. LV mass was significantly reduced after E (121.4 +/- 25.6 vs 104.6 +/- 13.7 g/cm2). The LV systolic function was unchanged after E, but LV diastolic function improved. It was shown that the long-term administration of E improves LV hypertrophy and LV diastolic function without any change of RAS.
本研究旨在探讨依那普利(E)对高血压患者左室(LV)质量、左室功能及血肾素-血管紧张素(RA)的影响。16例高血压患者纳入本研究(WHO I 8, WHO II 8, 49.5±10.5岁)。他们被检查了血压和心率。研究E给药前后约6个月的胸部x线片、超声心动图(echo)、x线计算机断层扫描(CT)和RA。CT计算左室质量。用回声法测定LV功能。RAS在本研究中没有变化。术后左室质量显著降低(121.4 +/- 25.6 vs 104.6 +/- 13.7 g/cm2)。E后左室收缩功能无变化，但左室舒张功能有所改善。结果表明，长期服用E可改善左室肥厚和左室舒张功能，而RAS无明显变化。
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