[Unusual course of glioblastoma multiforme as calcinosis in CCT].

Abstract

We report about a rare case of multifocal bihemispheric glioblastoma (WHO grade IV) with unusual course: At time of histological diagnosis via open biopsy and subtotal tumor resection right parieto-occipital the tumorous lesion presents itself for nine months unchanged as a little calcification right parietal, before developing in CCT multiocular bihemispheric hyperdens-hypodens areals with margin contrast enhancement and perifocal edema within one month. Tumor histogenesis of this special case is discussed contrasting the embryogenetic concept with the concept of tumor-grading. From clinical relevance is the fact that even a long time unchanged unifocal calcification in CCT could be the first sign of developing glioblastoma, and so short-term clinical and computer tomographic controls are necessary.