Transmigration routes and a delayed systemic hypotension in rats after intraperitoneal injection of endotoxin from Escherichia coli.

Circulatory shock Pub Date : 1993-11-01
K Sugimoto, M Kawamura, M Katori, M Shindo, T Ohwada
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Abstract

An intraperitoneal injection of endotoxin (ETX; 3 mg/kg) to rats caused gradual decrease in the systemic arterial blood pressure for up to 3 hr, together with decrease in heart rate, increase in hematocrit, and changes in the core temperature (an initial increase and a subsequent decrease). Pretreatment of rats with indomethacin (10 mg/kg, p.o.) prevented the decrease in the systemic blood pressure and the changes in other three parameters. The intraperitoneal injection of ETX also induced a gradual increase in exudation of plasma for up to 3 hr, with increased levels of prostaglandin (PG) E2 and 6-keto-PGF1 alpha in the peritoneal exudate. Indomethacin inhibited the exudation of plasma. The levels of ETX in the arterial and portal venous plasmas began to increase 5 min after the intraperitoneal injection of ETX, and reached levels on the order of micrograms per milliliter plasma 10-20 min after the injection. The levels of ETX in the right and left thoracic lymph nodes, but not in the mesenteric lymph nodes, increased in parallel with those in the systemic arterial plasma. In conclusion, the delayed hypotension may be attributable to the mesenteric vasodilatation induced by PGs generated in the peritoneal cavity, and the ETX injected entered the systemic circulation mainly through lymphatic vessels, but in the initial stage, a part of ETX may be transmigrated into portal vein through damaged intestine.

腹腔注射大肠杆菌内毒素后大鼠的转运途径和迟发性全身性低血压。
腹腔注射内毒素(ETX;3 mg/kg)引起大鼠全身动脉血压逐渐下降,持续3小时,同时心率下降,红细胞压积增加,核心温度变化(最初升高,随后降低)。吲哚美辛(10mg /kg, p.o.)预处理大鼠对全身血压的降低及其他3项指标的改变均有抑制作用。腹腔注射ETX也诱导血浆渗出量逐渐增加长达3小时,并增加了腹膜渗出液中前列腺素(PG) E2和6-酮- pgf1 α的水平。吲哚美辛抑制血浆渗出。腹腔注射ETX后5 min动脉和门静脉血浆中ETX水平开始升高,注射后10 ~ 20 min达到微克/毫升血浆水平。左、右胸椎淋巴结的ETX水平与全身动脉血浆水平平行升高,但肠系膜淋巴结未见ETX水平升高。综上所述,迟发性低血压可能与腹膜腔内产生的PGs引起肠系膜血管扩张有关,注射的ETX主要通过淋巴管进入体循环,但在初始阶段,部分ETX可能通过受损的肠道转移到门静脉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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