{"title":"Human recombinant lipocortin 1 (annexin 1) has anticoagulant activity on human plasma in vitro.","authors":"G Cirino, C Cicala","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Lipocortin 1 is a member of a group of calcium and phospholipid binding proteins named lipocortins (Di Rosa et al. (1984) Prostglandins 28, 441-442) and also known as annexins (Crumpton (1990) Nature 345, 212). In this study we have shown that human recombinant lipocortin-1 can increase the activated partial thromboplastin time but not the prothrombin time of human plasma in vitro. This effect is dose and time dependent and is reversed by polyclonal anti-lipocortin-1 antibodies. To our knowledge, this is the first demonstration that the human recombinant protein has the same activity as the native protein on human plasma.</p>","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"8 2","pages":"81-6"},"PeriodicalIF":0.0000,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of lipid mediators","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Lipocortin 1 is a member of a group of calcium and phospholipid binding proteins named lipocortins (Di Rosa et al. (1984) Prostglandins 28, 441-442) and also known as annexins (Crumpton (1990) Nature 345, 212). In this study we have shown that human recombinant lipocortin-1 can increase the activated partial thromboplastin time but not the prothrombin time of human plasma in vitro. This effect is dose and time dependent and is reversed by polyclonal anti-lipocortin-1 antibodies. To our knowledge, this is the first demonstration that the human recombinant protein has the same activity as the native protein on human plasma.