Strategies for cytokine utilisation in tumor therapy.

F Di Pierro, F Cavallo, F Pericle, S Bertini, M Giovarelli, G Forni
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引用次数: 6

Abstract

The state of the art with regard to the employment of various cytokine-based tumor immunotherapy strategies and their mechanisms of action are critically reviewed. As matters now stand, adoptive transfer of LAK cells or tumor infiltrating lymphocytes together with high doses of IL-2 constitutes the only immunologic way to hinder tumor growth in advanced stages of cancer. On the other hand, many experimental data show that the local presence of cytokines, either injected repeatedly at tumor site or released by cytokine-gene engineered tumor cells, arouses immunogenicity in apparently nonimmunogenic spontaneous tumors. By strengthening the notion that most tumors are potentially immunogenic, these findings offer substantial evidence to stress the potential use of cytokines as a component of new tumor vaccines.

细胞因子在肿瘤治疗中的应用策略。
本文对各种基于细胞因子的肿瘤免疫治疗策略及其作用机制的最新进展进行了综述。目前看来,LAK细胞过继性转移或肿瘤浸润淋巴细胞结合高剂量IL-2是阻碍晚期癌症肿瘤生长的唯一免疫途径。另一方面,许多实验数据表明,细胞因子的局部存在,无论是在肿瘤部位反复注射,还是由细胞因子基因工程的肿瘤细胞释放,在明显无免疫原性的自发性肿瘤中引起免疫原性。通过强化大多数肿瘤具有潜在免疫原性的概念,这些发现为强调细胞因子作为新肿瘤疫苗组成部分的潜在用途提供了大量证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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