A quantitative study of levodopa-induced dyskinesia in Parkinson's disease.

M P Caligiuri, S Peterson
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引用次数: 8

Abstract

The present study addressed the question of whether the emergence and severity of levodopa-induced dyskinesia was related to the therapeutic benefits derived from levodopa. Eight PD patients with clinically observed levodopa-induced dyskinesia were studied prior to and for two hours following a single dose of Sinemet (carbidopa/levodopa). Quantitative instrumental procedures were used to assess upper extremity dyskinesia, rigidity and bradykinesia. Results indicated that all patients exhibited significant reduction in their parkinsonism within 45 minutes following treatment. Reduction in bradykinesia, but not rigidity appeared to coincide with the emergence of dyskinesia. There was a significant relationship between severity of dyskinesia and the degree of improvement in movement velocity but not rigidity. Further analyses revealed that this relationship depended largely on the age of the patient. These findings are discussed as they pertain to a unified model of basal ganglia movement disorders which places dyskinesia and bradykinesia at opposite extremes along a continuum.

左旋多巴诱导帕金森病运动障碍的定量研究。
本研究探讨了左旋多巴引起的运动障碍的出现和严重程度是否与左旋多巴的治疗效果有关。研究了8例临床观察到左旋多巴诱导的运动障碍的PD患者,在单剂量Sinemet(卡比多巴/左旋多巴)之前和之后2小时。采用定量仪器程序评估上肢运动障碍、僵硬和运动迟缓。结果表明,所有患者在治疗后45分钟内帕金森症状明显减轻。运动迟缓的减少,而不是僵硬,似乎与运动障碍的出现一致。运动障碍的严重程度与运动速度的改善程度有显著关系,但与僵硬程度无关。进一步的分析表明,这种关系在很大程度上取决于患者的年龄。这些发现被讨论,因为他们属于一个统一的模型基底神经节运动障碍,运动障碍和运动迟缓在对立的极端沿连续体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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