4',6-diamidino 2-phenylindole is a new reversible inhibitor of diamine oxidase and S-adenosyl-l-methionine decarboxylase from mammalian tissues

Abstract

1. 4',6-Diamidino-2-phenylindole is a powerful reversible inhibitor of porcine kidney diamine oxidase and partially purified rabbit liver $\text{S-}\text{adenosyl-}\text{L}\text{-methionine}$ decarboxylase.

2. This diamidine has shown to be a competitive inhibitor of porcine kidney diamine oxidase with a Ki value of 13μM.

3. A similar inhibitory pattern has been found on rat liver $\text{S-}\text{adenosyl-}\text{L}\text{-methionine}$ decarboxylase with an estimated Ki of 21 μM.