The effects of synthetic thymopoietin on binding of α-bungarotoxin to rat neural membranes

Abstract

Chemically synthesized bovine thymopoietin I (TPO-I) and thymopoietin II (TPO-II) were evaluated as inhibitors of ¹²⁵I α-Bungarotoxin binding to rat brain neural membranes and found to be over 1,000 × less potent ($\text{IC}{}_{50}\text{= 10μ}\text{M}$) than reported for thymopoietin isolated from bovine thymus.