Correlations between the molecular structures of polyhalogenated biphenyls and their metabolism by hepatic microsomal monooxygenases

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI:10.1016/0742-8413(93)90066-T

J.T. Borlakoglu , J.P.G. Wilkins

{"title":"Correlations between the molecular structures of polyhalogenated biphenyls and their metabolism by hepatic microsomal monooxygenases","authors":"J.T. Borlakoglu , J.P.G. Wilkins","doi":"10.1016/0742-8413(93)90066-T","DOIUrl":null,"url":null,"abstract":"<div>1. Collation of the data presented in the preceding papers (references 4,5) showed a significant correlation (r = 0.83; P < 0.001) between the molecular mass (and hence the extent of halosubstitution) of halogenated biphenyls and their rate of hydroxylation by hepatic microsomal monooxygenases.2. There was no relationship between the extent of polyortho halosubstitution of biphenyl and the rate of metabolism.3. A marginal correlation (r = 0.33; P < 0.001) was found when the number of adjacent unsubstituted meta-para positions were linked to the rate of metabolism of PCBs. This structural feature facilitates microsomal oxidation.4. The results support the proposal that PCBs with meta-para hydrogen atoms are less enriched in tissues of animals and humans as this structural feature favours their metabolism by P450 isoenzymes.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 1","pages":"Pages 113-117"},"PeriodicalIF":0.0000,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90066-T","citationCount":"25","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/074284139390066T","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 25

Abstract

1. Collation of the data presented in the preceding papers (references 4,5) showed a significant correlation (r = 0.83; P < 0.001) between the molecular mass (and hence the extent of halosubstitution) of halogenated biphenyls and their rate of hydroxylation by hepatic microsomal monooxygenases.

2. There was no relationship between the extent of polyortho halosubstitution of biphenyl and the rate of metabolism.

3. A marginal correlation (r = 0.33; P < 0.001) was found when the number of adjacent unsubstituted meta-para positions were linked to the rate of metabolism of PCBs. This structural feature facilitates microsomal oxidation.

4. The results support the proposal that PCBs with meta-para hydrogen atoms are less enriched in tissues of animals and humans as this structural feature favours their metabolism by P450 isoenzymes.

查看原文本刊更多论文

多卤联苯分子结构与肝微粒体单加氧酶代谢的关系

1. 对上述文献(文献4,5)的数据进行整理后发现，两者之间存在显著的相关性(r = 0.83;P & lt;0.001)，即卤代联苯的分子质量(以及由此产生的卤代程度)与它们被肝微粒体单加氧酶羟基化的速率之间的关系。联苯的多卤代取代程度与代谢速率无相关性。边际相关性(r = 0.33;P & lt;0.001)，当相邻未取代的间位位置的数量与多氯联苯的代谢速率相关时，发现。这种结构特征有利于微粒体氧化。结果支持了具有间对氢原子的多氯联苯在动物和人类组织中的富集程度较低的建议，因为这种结构特征有利于它们被P450同工酶代谢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Comparative biochemistry and physiology. C: Comparative pharmacology

自引率

0.00%

发文量