{"title":"Involvement of eicosanoids and inositol 1,4,5-trisphosphate in serotonin-induced secretion in rat ileum in vivo","authors":"Mark Berner Hansen, Bernard M. Jaffe","doi":"10.1016/0742-8413(93)90061-O","DOIUrl":null,"url":null,"abstract":"<div><p>1. The possible involvement of eicosanoids, cyclic adenosine monophosphate (c-AMP), and inositol 1,4,5-trisphosphate (IP<sub>3</sub>) in serotonin-(5-hydroxytryptamine-) induced secretion in rat ileum <em>in vivo</em> was studied.</p><p>2. Serotonin caused a significant increase in mean Ip<sub>3</sub> levels. Indomethacin reduced serotonin-induced secretion of water by 28%. Thus, Ip<sub>3</sub> and eicosanoids appear to be intracellular mediators of serotonin-induced secretion in rat ileum.</p><p>3. Serotonin, BRL 24924, and cisapride all inhibited theophylline-induced increases in c-AMP concentrations in rat ileal segments. Neither BRL 24924 nor cisapride caused any change in Ip<sub>3</sub> levels.</p><p>4. These data suggest that a 5-HT<sub>2</sub> receptor dependent on Ip<sub>3</sub> and eicosanoids is involved in mediating in serotonin-induced secretion in rat small intestine.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 1","pages":"Pages 77-82"},"PeriodicalIF":0.0000,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90061-O","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/074284139390061O","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
1. The possible involvement of eicosanoids, cyclic adenosine monophosphate (c-AMP), and inositol 1,4,5-trisphosphate (IP3) in serotonin-(5-hydroxytryptamine-) induced secretion in rat ileum in vivo was studied.
2. Serotonin caused a significant increase in mean Ip3 levels. Indomethacin reduced serotonin-induced secretion of water by 28%. Thus, Ip3 and eicosanoids appear to be intracellular mediators of serotonin-induced secretion in rat ileum.
3. Serotonin, BRL 24924, and cisapride all inhibited theophylline-induced increases in c-AMP concentrations in rat ileal segments. Neither BRL 24924 nor cisapride caused any change in Ip3 levels.
4. These data suggest that a 5-HT2 receptor dependent on Ip3 and eicosanoids is involved in mediating in serotonin-induced secretion in rat small intestine.
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