Methylglyoxal and cell viability

László Braun, Tamás Garzó, Pál Riba , József Mandl, Miklós Péter Kalapos
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引用次数: 13

Abstract

  • 1.

    1. Methylglyoxal by depleting glutathione stores increased Trypan-blue uptake by the cells incubated in glucose, pyruvate and amino acids free medium.

  • 2.

    2. Only a transient fall of glutathione concentration without any effect on cell viability was caused by methylglyoxal when the medium was supplemented with above-mentioned compounds.

  • 3.

    3. The role of gamma-glutamyl-transpeptidase is discussed.

甲基乙二醛和细胞活力
1.1. 通过消耗谷胱甘肽储存的甲基乙二醛增加了在葡萄糖、丙酮酸和无氨基酸培养基中培养的细胞对台锥蓝的摄取。当培养基中添加上述化合物时,甲基乙二醛只引起谷胱甘肽浓度的短暂下降,对细胞活力没有影响。讨论了γ -谷氨酰转肽酶的作用。
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