Facilitation of retinal function recovery by natural products after temporary ischemic occlusion of central retinal artery.

G C Chiou, B H Li, M S Wang
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引用次数: 19

Abstract

The b-wave of electroretinogram (ERG) was used as an indicator of the retinal function in this research to study the facilitation of retinal function recovery by some natural products isolated from medicinal plants. The retinal ischemia was induced by occlusion of the central retinal artery. It was found that the recovery of b-waves was limited to approximately 30-37% in control animals, whereas the b-wave recovery was doubled by natural products, including scoparone, corylifolinin and EGCG (epigallocatechin-3-0-gallate). Lespedeza flavanone A had biphasic action by suppressing the b-wave recovery below control level initially, then enhancing the b-wave recovery over the control rate later. These results indicate that some natural products could be used for the treatment of ischemic retinopathy.

视网膜中央动脉暂时性缺血性闭塞后天然产物促进视网膜功能恢复。
本研究以视网膜电图b波(ERG)作为视网膜功能的指标,研究药用植物天然产物对视网膜功能恢复的促进作用。视网膜中央动脉闭塞导致视网膜缺血。结果发现,在对照动物中,b波的回收率限制在约30-37%,而天然产物,包括天scoparone,石竹油苷和EGCG(表没食子儿茶素-3-0-没食子酸酯)的b波回收率增加了一倍。胡子黄酮A具有双相作用,先抑制b波恢复低于对照水平,后提高b波恢复高于对照水平。这些结果表明,一些天然产物可用于缺血性视网膜病变的治疗。
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