[Treatment of severe forms of Langerhans cell histiocytosis].

Abstract

Langerhans cell histiocytosis is a non malignant disorder of immune regulation. Patients with multisystem disease and organ dysfunction are considered to have a poor prognosis, and particularly children younger than 2 years of age. Clinical trials using human alpha-interferon, cyclosporine A and bone marrow transplantation have been reported recently.