[Lectin-histochemical characteristics of bone tumors. I. Stage-related changes in lectin-binding of giant cells in osteoclastoma].

Abstract

Authors examined 18 cases of osteoclastoma chosen at random with different lectins. The fibroblast-like type I stromal cells taking part in the formation of the ground substance were Con A positive. The strength of the Con A bond and the number of positive cells increased with the progress of the stage. The PNA lectin bond following the digestion with neuraminidase was in the single stages of different character and intensity. Whereas in the Gr I osteeoclastomas 30 per cent of the reacting osteoclast was localized to a well defined segment of the membrane in the Gr III tumors the ratio of the negative cells moved around 1 per cent, and in 60 per cent of the positive cells strong diffuse intracytoplasmatic reaction could be observed. Authors think that the lectin histochemical examinations give help to the definition of the activity of the tumor forming cells.