[Pathogenesis of atherosclerosis in diabetes mellitus. The role of insulin resistance and hyperinsulinemia].

Fiziologicheskiĭ zhurnal Pub Date : 1993-09-01
E p Kostiuk, S T Zubkova
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Abstract

The review summarizes data about interconnection between atherosclerosis and diabetes mellitus. Special attention is paid to their joint developmental factors such as hyperinsulinemia and insulin resistance. It is shown that hyperinsulinemia may form an independent risk factor. At the same time both factors can lead (during both diabetes mellitus and atherosclerosis) to changes in lipid metabolism and development of atheroms. Mechanisms of the development of insulin resistance and hyperinsulinemia are analyzed. The so-called syndrome X is described in detail. It is characterized by a triad of changes: insulin resistance and hyperinsulinemia, changes in lipid metabolism and hypertension. Some methods of treatment of insulin resistance and hyperinsulinemia during atherosclerosis and diabetes mellitus are described.

糖尿病动脉粥样硬化的发病机制。胰岛素抵抗和高胰岛素血症的作用]。
本文综述了动脉粥样硬化与糖尿病之间关系的相关资料。特别关注他们的共同发育因素,如高胰岛素血症和胰岛素抵抗。结果表明,高胰岛素血症可能是一个独立的危险因素。同时,这两种因素都可以导致(在糖尿病和动脉粥样硬化期间)脂质代谢的改变和动脉粥样硬化的发生。分析了胰岛素抵抗和高胰岛素血症的发生机制。详细描述了所谓的X综合征。它的特点是三个变化:胰岛素抵抗和高胰岛素血症,脂质代谢的变化和高血压。本文介绍了动脉粥样硬化和糖尿病中胰岛素抵抗和高胰岛素血症的一些治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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