Does weight for height have prognostic significance in children with acute lymphoblastic leukemia?

The American journal of pediatric hematology/oncology Pub Date : 1994-08-01 DOI:10.1097/00043426-199408000-00007

J J Reilly, I Odame, J H McColl, P J McAllister, B E Gibson, B A Wharton

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引用次数: 46

Abstract

Purpose: We tested the hypothesis that weight for height, a simple index of nutritional status, is related to prognosis in childhood acute lymphoblastic leukemia (ALL).

Patients and methods: The study population was composed of 78 children with ALL tested at one U.K. center on the same protocol (UKALL-X). Outcome measures were relapse/no relapse and time to first relapse. Influence of weight for height, expressed as standard deviation scores, was tested using survival analysis in a retrospective design.

Results: The weight-for-height standard deviation score had a significant influence on time until first relapse (log ranks test, p = 0.012), with the highest risk of early relapse in children at the lower end of the weight-for-height distribution.

Conclusions: The results suggest that weight for height does have an influence on outcome in ALL, but the mechanism is unclear and the finding requires confirmation by larger scale prospective studies.

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体重身高对急性淋巴细胞白血病患儿预后有影响吗?

目的:我们验证了体重与身高(营养状况的简单指标)与儿童急性淋巴细胞白血病(ALL)预后相关的假设。患者和方法:研究人群由78名患有ALL的儿童组成，他们在英国的一个中心接受了相同的治疗方案(UKALL-X)。结局指标为复发/无复发和首次复发时间。体重对身高的影响，以标准偏差分数表示，采用回顾性设计的生存分析进行检验。结果:身高体重标准差评分对首次复发时间有显著影响(对数秩检验，p = 0.012)，儿童早期复发风险最高的是身高体重分布的下端。结论:研究结果表明，身高体重对急性淋巴细胞白血病的预后有影响，但其机制尚不清楚，这一发现需要更大规模的前瞻性研究来证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The American journal of pediatric hematology/oncology

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