{"title":"Sleep oscillations in corticothalamic neuronal networks and their development into self-sustained paroxysmal activity.","authors":"M Steriade","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Electrophysiological studies in cats have shown that one of the most common forms of sleep oscillation, spindling, may develop into spike-and-wave discharges through repetitive spike-bursts transmitted along thalamocortical or corticothalamic axons. The lowered frequency (from around 10 Hz to 3 Hz) can be explained by the abnormally increased duration of an IPSP mediated by GABA receptors. The administration of ethosuximide has a twofold effect resulting in a diminished spindling activity of the reticular thalamic nucleus as well as a decrease in the incidence of epileptic spike-and-wave discharges. Self-sustained paroxysmal activity may develop during EEG synchronized states by repetitively setting into action reciprocally connected structures.</p>","PeriodicalId":77370,"journal":{"name":"Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Electrophysiological studies in cats have shown that one of the most common forms of sleep oscillation, spindling, may develop into spike-and-wave discharges through repetitive spike-bursts transmitted along thalamocortical or corticothalamic axons. The lowered frequency (from around 10 Hz to 3 Hz) can be explained by the abnormally increased duration of an IPSP mediated by GABA receptors. The administration of ethosuximide has a twofold effect resulting in a diminished spindling activity of the reticular thalamic nucleus as well as a decrease in the incidence of epileptic spike-and-wave discharges. Self-sustained paroxysmal activity may develop during EEG synchronized states by repetitively setting into action reciprocally connected structures.