Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys

Bao-Ming Li, Zhen-Tong Mei
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引用次数: 185

Abstract

Two young adult monkeys (Macaca mullata) were trained to perform a delayed-response task that required the monkeys to remember a cued spatial position (left or right) over a delay interval and then to make a response to the cued position. Local injection of the α2-adrenergic antagonist yohimbine (10 μg in 2 μl saline) into the dorsolateral prefrontal cortex (Walker's area 46 and area 9) impaired the performance of the delayed-response task, and it was without effect on the performance of the task if there was no delay between the cue and choice signals. The main performing error after injection of yohimbine was that the monkeys responded to uncued position with higher rate. Local injection of the α1-adrenergic antagonist prazosin (10 μg in 2 μl saline) or the β-adrenergic antagonist propranolol (10 μg in 2 μl saline) into the same cortical areas induced no significant effect on the performance of the task. The present study suggests that prefrontal α2-adrenoceptors play an important role in the spatial working memory in young adult monkeys.

α2-肾上腺素能拮抗剂育亨宾局部注射到年轻成年猴子的背外侧前额皮质诱导的延迟反应缺陷
两只年轻的成年猴子(Macaca mullata)被训练去执行一项延迟反应任务,该任务要求猴子在一段延迟间隔内记住提示的空间位置(左或右),然后对提示的位置做出反应。将α2-肾上腺素能拮抗剂育亨宾(10 μg, 2 μl生理盐水)局部注射到背外侧前额叶皮层(Walker’s区46和9区),可降低延迟反应任务的表现,而在提示和选择信号之间不存在延迟的情况下,育亨宾对延迟反应任务的表现无影响。育亨宾注射后的主要表现错误是猴子对未提示位置的反应率较高。α -肾上腺素能拮抗剂普拉唑嗪(10 μg / 2 μl生理盐水)或β-肾上腺素能拮抗剂普萘洛尔(10 μg / 2 μl生理盐水)局部注射于同一皮质区对任务表现无显著影响。本研究表明,α2-肾上腺素受体在空间工作记忆中起着重要的作用。
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