Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats

Abstract

• 1.

  1. Lipoperoxidation (LPx) and glutathione peroxidase (GPx) activity were measured in kidney, liver, heart, lung, brain and testis from control and puromycin aminonucleoside (PAN) injected rats on days 1–6, 8, 10, 16 and 22 after vehicle or PAN injection.

• 2.

  2. PAN-injected rats developed proteinuria on day 3.

• 3.

  3. In PAN-injected rats: (a) LPx increased in kidney, liver, lung, brain and testis before day 3 and in heart on day 3; (b) GPx activity increased in kidney, liver, heart, lung and testis and diminished in brain on day 3 or after.