Changes in muscle and liver lactate concentrations after endotoxin infusion in rats.

Circulatory shock Pub Date : 1994-08-01
M Harada, C Okuda, T Sawa, A Fuse, H Imai, Y Tanaka
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Abstract

The interstitial lactate concentration in rat skeletal muscle and liver was measured using a microdialysis method during the early stage of endotoxemia and during lactic acid infusion. The lactate concentration in the muscle and liver interstitium never exceeded the blood lactate concentration throughout the 180 min period after endotoxin administration. The present findings also showed that the muscle and liver interstitial lactate concentration gradually increased in endotoxin-infused animals compared to that in lactic-acid infused animals, although the blood lactate concentration in lactic acid-infused animals was the same as that in endotoxin-infused animals. These findings suggest that the skeletal muscle and liver may consume lactate in an endotoxemic condition. However, the capacity of lactate consumption in the skeletal muscle might gradually decrease after endotoxin administration, although that in liver might be well preserved.

内毒素输注后大鼠肌肉和肝脏乳酸浓度的变化。
采用微透析法测定内毒素血症早期和乳酸输注时大鼠骨骼肌和肝脏间质乳酸浓度。在给药后180 min内,肌肉和肝间质乳酸浓度均未超过血乳酸浓度。本研究还发现,虽然乳酸灌注动物的血乳酸浓度与内毒素灌注动物相同,但内毒素灌注动物的肌肉和肝脏间质乳酸浓度较乳酸灌注动物逐渐升高。这些发现表明骨骼肌和肝脏可能在内毒素条件下消耗乳酸。然而,内毒素给药后,骨骼肌乳酸消耗能力可能逐渐下降,而肝脏乳酸消耗能力可能保留得很好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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