Clinicopathological study of lymphomas in the central nervous system--with the reference to the recurrence and proliferative activity.

Abstract

Nine cases of CNS lymphomas obtained by surgical resection or biopsy between 1984 and 1991 were examined. One case of intraorbital lymphoma was also studied. All patients underwent radiotherapy. In addition, 7 underwent steroid therapy and 4 underwent chemotherapy. The case comprised the following (LSG classification): small cell type (3), medium cell type (1), large cell type (3), and medium and large cell type (3). Immunohistochemically, LCA and B-26 immunopositivity were seen in all cases. Cytoplasmic Ig immunopositivity was observed in five cases. The mean AgNORs number was 4.63 (range: 1.8-7.2). The mean PCNA SI was 26.75 (range: 10.2-39.7). No correlation was found between LSG classification and proliferative activity. Although no correlation was found between AgNORs number and recurrence, the recurrent group showed tendency to have more AgNORs that the non-recurrent group. Although no correlation was found between PCNA SI and recurrence, the recurrent group showed tendency to have a higher PCNA SI than the non-recurrent group. The proliferative activity in AgNORs and PCNA studies may be considered as a prognostic indicator in CNS lymphomas.