Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery

Oral Surgery, Oral Medicine, Oral Pathology Pub Date : 1994-11-01 DOI:10.1016/0030-4220(94)90165-1

A.J. van der Westhuijzen BChD, MChD (FFD(SA), FDSRCS(Eng)) , J.A. Roelofse MBChB, MMed, PhD , F.W. Grotepass BChD, MChD (Professor and Head) , P.J. Becker PhD

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引用次数: 30

Abstract

Objective. This study compares the effectiveness of tiaprofenic acid with diclophenac sodium over a 7-day period with respect to pain, facial swelling, and trismus.

Study design. Sixty patients who required general anesthesia for removal of bilateral impacted third molar teeth were included. Intraoperatively, they received intramuscular injections of either tiaprofenic acid or diclophenac sodium followed respectively by tiaprofenic acid tablets for 5 days and placebo for an additional 2 days or diclophenac sodium tablets for the full 7 days. Surgical and anesthetic techniques were standardized. Pain levels were compared hourly for 4 hours postoperatively and thereafter twice daily for 7 days. Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively.

Results. No statistically significant difference was found between the two treatment groups with respect to pain or facial swelling. Only with respect to recovery in mouth-opening ability (trismus) from day 2 to day 7 did diclophenac sodium reveal a statistically significant advantage (p = 0.0452).

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第三磨牙手术后tiaprofenic acid和双氯芬酸钠的随机双盲比较

目标。本研究比较了tiaprofenic acid与双氯芬酸钠在7天内对疼痛、面部肿胀和牙关紧闭的疗效。研究设计。本文包括60例需要全麻切除双侧阻生第三磨牙的患者。术中，患者肌肉注射tiaprofenic acid或双氯芬酸钠，随后分别服用tiaprofenic片剂5天，安慰剂2天或双氯芬酸钠片整整7天。手术和麻醉技术标准化。术后4小时每小时比较疼痛水平，此后每天2次，持续7天。比较术后第2天和第7天面部肿胀和牙关的变化。两个治疗组在疼痛和面部肿胀方面没有统计学差异。只有在第2天至第7天的开口能力(咬牙)恢复方面，双氯芬酸钠显示出统计学上显著的优势(p = 0.0452)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral Surgery, Oral Medicine, Oral Pathology

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