Insulin-like growth factor I correlations to changes of the hormonal status in puberty and age.

V Hesse, G Jahreis, H Schambach, H Vogel, C Vilser, H J Seewald, A Börner, A Deichl
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引用次数: 33

Abstract

IGF-I is considered to be one of the most important growth factors during puberty. Information concerning its correlation to thyroid hormones (T3, T4), adrenal and sex steroids is limited to puberty and the elderly. The presented study included 455 subjects (among them 259 children) ranging in age from newborn to 100 years. Serum IGF-I concentrations increase from childhood to the end of puberty (2 years earlier in girls). There are close positive correlations between IGF-I concentrations and age, height and weight and between IGF-I and estradiol or testosterone concentration in girls and boys respectively, and the DHEA-S level in boys during puberty. Correlations also exist with T3, aldosterone and 17 OH-progesterone in boys and girls in the pubertal stages I-V and with T4 in stages I-IV. Compared to 20-30 year-old subjects IGF-I concentrations amounted to 59% after 60 years, 43% in men and 54% in women after 70 years and 29% after 90 years. It is suggested that increasing adrenal DHEA-S concentrations stimulate IGF-I synthesis and by means of gonadal steroidogenesis, increase the pubertal GH secretion and the further pubertal IGF-I increase. The low IGF-I concentrations in patients > 60 years reflect the more catabolic metabolism of the elderly.

胰岛素样生长因子I与青春期和年龄荷尔蒙状态变化的相关性。
igf - 1被认为是青春期最重要的生长因子之一。有关其与甲状腺激素(T3、T4)、肾上腺激素和性类固醇相关的信息仅限于青春期和老年人。该研究包括455名受试者(其中259名儿童),年龄从新生儿到100岁不等。血清igf - 1浓度从儿童期到青春期结束(女孩早2年)增加。青春期女孩和男孩的IGF-I浓度分别与年龄、身高、体重、雌二醇或睾酮浓度、男孩的DHEA-S水平呈正相关。男孩和女孩在青春期I-V期与T3、醛固酮和17 oh -孕酮存在相关性,在青春期I-IV期与T4存在相关性。与20-30岁受试者相比,60岁后IGF-I浓度为59%,70岁后男性为43%,女性为54%,90岁后为29%。提示肾上腺DHEA-S浓度的升高刺激了IGF-I的合成,并通过性腺类固醇生成,增加了青春期GH的分泌,进一步提高了青春期IGF-I的水平。> 60岁的患者IGF-I浓度较低,反映了老年人更多的分解代谢。
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