A clinical trial of antioxidant supplements in the treatment of oral leukoplakia

Oral Surgery, Oral Medicine, Oral Pathology Pub Date : 1994-10-01 DOI:10.1016/0030-4220(94)90039-6

George E. Kaugars DDS (Professor) , Sol Silverman Jr. MA, DDS (Professor) , John G.L. Lovas DDS (Associate Professor) , Richard B. Brandt PhD (Professor) , William T. Riley PhD (Associate Professor) , Quyen Dao BS (Graduate Student) , Vishwa N. Singh PhD (Assistant Director) , John Gallo BS, MT (Certified Medical Technologist)

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引用次数: 85

Abstract

Seventy-nine patients with oral leukoplakia that was histologically verified as either hyperkeratosis or epithelial dysplasia with hyperkeratosis were enrolled in an antioxidant supplementation program for the treatment of the oral lesions. The patients received 30 mg of beta-carotene, 1000 mg of ascorbic acid, and 800 IU of alpha-tocopherol per day for 9 months. Clinical improvement of the oral lesion was noted in 55.7% of the patients and was more likely to occur in patients who reduced their use of alcohol or tobacco (p = 0.0056). Although risk-factor reduction was important, approximately half of the patients who did not alter their exposure to either alcohol or tobacco showed clinical improvement. The antioxidant supplementation significantly increased serum and tissue levels of beta-carotene, ascorbic acid, and alpha-tocopherol, but these changes did not correlate strongly with clinical improvement.

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抗氧化补充剂治疗口腔白斑的临床试验

79例经组织学证实为角化过度或上皮发育不良伴角化过度的口腔白斑患者被纳入抗氧化剂补充计划，以治疗口腔病变。患者每天服用30毫克β -胡萝卜素，1000毫克抗坏血酸和800国际单位α -生育酚，持续9个月。55.7%的患者出现口腔病变的临床改善，减少饮酒或吸烟的患者更有可能出现口腔病变的临床改善(p = 0.0056)。虽然减少风险因素很重要，但在不改变烟酒暴露的患者中，约有一半的患者表现出临床改善。抗氧化剂的补充显著增加了血清和组织中β -胡萝卜素、抗坏血酸和α -生育酚的水平，但这些变化与临床改善没有很强的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral Surgery, Oral Medicine, Oral Pathology

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