The effect of distension of the stomach on plasma renin activity in the anesthetized pig.

Cardioscience Pub Date : 1994-12-01
G Vacca, E Chiorboli, E Grossini, B Papillo
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Abstract

It has recently been shown that distension of the stomach in anesthetized pigs causes reflex hemodynamic responses through efferent sympathetic mechanisms. The present study was undertaken to investigate whether these mechanisms include activation of the renin-angiotensin system. In twelve anesthetized pigs, intragastric balloons were distended for periods of 30 minutes by 0.81 of warm Ringer solution (mean gastric transmural pressure of about 12 mmHg). Changes in arterial blood pressure and heart rate were respectively prevented by a pressurized reservoir connected to the left femoral artery and by atrial pacing. Plasma renin activity was measured during the last minute of distension by radioimmunoassay of angiotensin I. In each of the twelve pigs distension of the stomach caused an increase in plasma renin activity. In five pigs, this response was graded with step increments of the distension. The increase in plasma renin activity to gastric distension was abolished by bilateral subdiaphragmatic vagotomy (six pigs) and by bilateral section of the renal nerves (six pigs). The present study showed that innocuous distension of the stomach in the anesthetized pig reflexly increased plasma renin activity. The afferent limb of the reflex was in the vagal nerves and the efferent limb involved renal nerves.

胃扩张对麻醉猪血浆肾素活性的影响。
最近有研究表明,麻醉猪胃的膨胀通过传出交感神经机制引起反射性血流动力学反应。本研究旨在探讨这些机制是否包括肾素-血管紧张素系统的激活。在12只麻醉猪中,用0.81温林格液(平均胃壁压约12 mmHg)将胃内气球膨胀30分钟。动脉血压和心率的变化分别通过与左股动脉相连的加压储层和心房起搏来预防。在胃胀的最后一分钟,用血管紧张素i放射免疫法测定血浆肾素活性。在12头猪中,每头猪的胃胀引起血浆肾素活性增加。在五头猪中,这种反应随着膨胀的逐步增加而分级。双侧膈下迷走神经切开术(6头猪)和双侧肾神经切开术(6头猪)消除了血浆肾素活性对胃膨胀的增加。本研究表明,麻醉猪胃的无害膨胀反射性地增加血浆肾素活性。反射的传入肢位于迷走神经,传出肢累及肾神经。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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