Structure and function of Saccharomyces cerevisiae casein kinase II.

Abstract

Analysis of casein kinase II in organisms amenable to genetic manipulation is essential to elucidating the physiological function(s) of this ubiquitous protein kinase. This paper summarizes work from our laboratory on the enzyme from Saccharomyces cerevisiae. The biochemistry, molecular biology, and genetics of S. cerevisiae casein kinase II are reviewed and discussed.