Activity of p-aminobenzoic acid compared with other organic acids against selected bacteria.

R M Richards, D K Xing, T P King
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引用次数: 59

Abstract

The antibacterial activity of p-aminobenzoic acid against Listeria monocytogenes, Salmonella enteritidis and Escherichia coli was compared with the activity of commonly used acidulants: formic, propionic, acetic, lactic and citric acids. Viable count evaluations and MIC determinations indicated that p-aminobenzoic acid caused greater inhibitory effects than the other organic acids. The activity of p-aminobenzoic acid on the growth of the test organisms at selected pH values indicated that p-aminobenzoic acid was more active at low pH than at high pH. Uptake studies showed that the uptake of p-aminobenzoic acid by E. coli was markedly decreased as the pH values increased. Electron micrographs of E. coli cells grown in the presence of p-aminobenzoic acid indicate that p-aminobenzoic acid caused marked damage to the cell envelope. It is suggested that p-aminobenzoic acid has at least two mechanisms of action: one mechanism in common with other organic acids and the other mechanism by interfering with the synthesis of the peptidoglycan layer by an action on the dihydrofolate reductase enzyme.

对氨基苯甲酸与其他有机酸对选定细菌的活性比较。
对氨基苯甲酸对单核增生李斯特菌、肠炎沙门氏菌和大肠杆菌的抑菌活性与常用酸化剂甲酸、丙酸、乙酸、乳酸和柠檬酸的抑菌活性进行了比较。活菌计数和MIC测定表明,对氨基苯甲酸比其他有机酸具有更大的抑制作用。在选定的pH值下,对氨基苯甲酸对试验生物生长的活性表明,对氨基苯甲酸在低pH值下比在高pH值下更有活性。摄取研究表明,随着pH值的增加,大肠杆菌对对氨基苯甲酸的摄取明显减少。在对氨基苯甲酸存在下生长的大肠杆菌细胞的电子显微照片表明,对氨基苯甲酸对细胞包膜造成了明显的损伤。对氨基苯甲酸至少有两种作用机制:一种与其他有机酸有共同的作用机制,另一种作用机制是通过对二氢叶酸还原酶的作用干扰肽聚糖层的合成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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