Multisite clinical trials in alcoholism treatment research: organizational, methodological and management issues.

R K Fuller, M E Mattson, J P Allen, C L Randall, R F Anton, T F Babor
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引用次数: 25

Abstract

Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.

酒精中毒治疗研究的多地点临床试验:组织、方法和管理问题。
与单点研究相比,多点临床试验有两个主要优势:多点研究的大样本量允许足够的统计能力和更好的被研究人群代表性。然而,它们比单点研究实施起来更复杂。本文回顾了以往关于酒精滥用和酒精中毒的多地点临床试验,选择多地点设计的原因,这些研究的管理,以及一些统计问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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