Hydroxylated 22-carbon fatty acids in platelet and vascular smooth muscle function: interference with TXA2/PGH2 receptors.

J W Karanian, N Salem
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引用次数: 6

Abstract

Sub-micromolar levels of the lipoxygenase products of n-3 fatty acids specifically antagonize both the contractile effects of thromboxane (U46619) and its platelet aggregating effect. In addition, OH-22:6n3 inhibits thromboxane-induced decreases in cerebral blood flow of the rat. Analysis of binding parameters indicates these derivatives induce a marked decrease in the affinity of the TXA2/PGH2 receptor for thromboxane with a mild change in the number of receptor sites. The 22-carbon n-3 hydroxy fatty acids are the most potent biological antagonists of thromboxane in comparison to the n-6 hydroxy fatty acids and their parent fatty acids. Dietary permutations modify the hydroxy fatty acid profile and correlate with changes in thromboxane-mediated responses.

羟基化22碳脂肪酸在血小板和血管平滑肌功能中的作用:对TXA2/PGH2受体的干扰
亚微摩尔水平的n-3脂肪酸脂氧合酶产物特异性地拮抗血栓素(U46619)的收缩作用及其血小板聚集作用。此外,OH-22:6n3抑制血栓素引起的大鼠脑血流量减少。结合参数分析表明,这些衍生物诱导TXA2/PGH2受体对血栓素的亲和力显著降低,受体位点数量略有变化。与n-6羟基脂肪酸及其母体脂肪酸相比,22碳n-3羟基脂肪酸是最有效的血栓素生物拮抗剂。饮食排列改变了羟基脂肪酸谱,并与血栓素介导的反应变化相关。
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