{"title":"Comparison between clearance rates of plasma kallikrein and of plasma kallikrein-alpha-macroglobulin complexes by the liver.","authors":"H Ogata, M Kouyoumdjian, D R Borges","doi":"10.1016/0020-711x(93)90120-4","DOIUrl":null,"url":null,"abstract":"<p><p>1. alpha-Macroglobulins (alpha Ms) were isolated from the serum of injured rats through a two-stage method: gel filtration and ultracentrifugation. 2. The clearance rates of rat plasma kallikrein (RPK) and alpha Ms-RPK complexes were compared in an isolated rat liver perfusion system: the alpha Ms-RPK complexes are cleared at a much slower rate (half-life ranging from 24 to > 120 min) than does RPK itself (half-life ranging from 13 to 18 min).</p>","PeriodicalId":22539,"journal":{"name":"The International journal of biochemistry","volume":"25 7","pages":"1047-51"},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711x(93)90120-4","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0020-711x(93)90120-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
1. alpha-Macroglobulins (alpha Ms) were isolated from the serum of injured rats through a two-stage method: gel filtration and ultracentrifugation. 2. The clearance rates of rat plasma kallikrein (RPK) and alpha Ms-RPK complexes were compared in an isolated rat liver perfusion system: the alpha Ms-RPK complexes are cleared at a much slower rate (half-life ranging from 24 to > 120 min) than does RPK itself (half-life ranging from 13 to 18 min).
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