Effects of oral erythromycin on esophageal motility in patients with noninsulin-dependent diabetes mellitus.

S C Tsai, C H Kao, D Y Pan, S P ChangLai, S J Wang
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Abstract

Fifteen patients with non-insulin dependent diabetes mellitus (NIDDM) were included in the study. Esophageal motility, including esophageal mean transit time (MTT), residual fraction (RF), and retrograde index (RI), was evaluated and calculated by the radionuclide esophageal transit test (RETT). The baseline study was performed before the oral erythromycin therapy. After a 2-week course treatment, the subjects underwent a second study. The results showed that (A) in the baseline study, 93% (14/15) of NIDDM patients had a longer MTT, 67% (10/15) had a higher RF and 80% (12/15) had a higher RI; and (B) after treatment with erythromycin, 73% (11/15) of the patients had a shorter MTT and a lower RF, and 60% (9/15) of the patients had a lower RI. We conclude that (1) most of the NIDDM patients had esophageal motility disorders and (2) a 2-week oral erythromycin therapy can improve diabetic esophagoparesis, as evaluated by non-invasive REET.

口服红霉素对非胰岛素依赖型糖尿病患者食管运动的影响。
15例非胰岛素依赖型糖尿病(NIDDM)患者纳入研究。食道运动,包括食道平均传递时间(MTT)、残余分数(RF)和逆行指数(RI),通过放射性核素食道传递试验(RETT)进行评估和计算。基线研究在口服红霉素治疗前进行。2周疗程后,受试者进行第二次研究。结果显示(A)基线研究中,93%(14/15)的NIDDM患者MTT较长,67%(10/15)的RF较高,80%(12/15)的RI较高;(B)红霉素治疗后,73%(11/15)的患者MTT缩短,RF降低,60%(9/15)的患者RI降低。我们得出结论:(1)大多数NIDDM患者存在食管运动障碍;(2)通过无创REET评估,2周口服红霉素治疗可以改善糖尿病性食管炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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